Manipulating Cannabinoids

Trichome specific promoters: Tools to manipulate cannabinoid biosynthesis. Figure 3 from published US patent application No . : US 2019 / 0225975 : Assignee : 22nd Century Limited , LLC https://patents.google.com/patent/US20190225975A1/en. Sole inve…

Trichome specific promoters: Tools to manipulate cannabinoid biosynthesis. Figure 3 from published US patent application No . : US 2019 / 0225975 : Assignee : 22nd Century Limited , LLC https://patents.google.com/patent/US20190225975A1/en. Sole inventor Paul Rushton.

 
 

So Here’s the Secret!

The cannabinoid biosynthetic pathway occurs in trichomes and a main part of the pathway is linear - from hexanoate to CBG.

CBG is sometimes called the “Mother of Cannabinoids” because it is the cannabinoid from which THC, CBD, CBC and other cannabinoids are all derived.

Using non-GMO methods, that are non-proprietary, it is possible to manipulate this pathway very successfully.

  • Zero THC

  • Zero cannabinoids (perhaps the ideal variety for the hemp-derived food industry).

  • Higher CBG

  • Higher CBD

  • Higher CBC

  • Higher levels of other rare cannabinoids.

Now, developing a successful hemp variety that can be sold as seed to growers probably takes over 3 years of breeding (this is common in many crop plants).

However, if your goal is to develop a strain that makes large amounts of cannabinoids other than CBD or THC (for example CBG or CBC), then clonal production originating from a single mother plant could take as little as 18 months.

The result - differentiated products based on unique strains.

Everyone has CBD-based products but would you like CBC- or CBG-based ones?